Conferences

American Association for Cancer Research (AACR) Annual Meeting 2023; 2023 Apr 14-19; Orlando, FL

Posters acknowledging Oncobiome:

Abstract 6224: Exploring the integration of CMS subtyping and other omics in colorectal cancer classification and its reflection in stool miRNome and metagenome for non-invasive precision medicine
Amedeo Gagliardi; Giulia Francesca; Giulio Ferrero; Sonia Tarallo; Giulia Piaggeschi; Antonio Francavilla; Carla Di Battista; Enrico Berrino; Caterina Marchiò; Francesca Cordero; Barbara Pardini; Alessio Naccarati
Abstract 3797: Fecal miRNA profiles and gut metagenome composition in Lynch syndrome: results from a mouse model study and human subjects
Giulia Francescato; Giulio Ferrero; Marc Beltrà; Sonia Tarallo; Giulia Piaggeschi; Carla Di Battista; Antonio Francavilla; Carlijn Bruggeling; Fabio Penna; Barbara Pardini; Paola Costelli; Annemarie Boleij; Alessio Naccarati
This poster received the AACR-Pezcoller Foundation Scholar-in-Training Awards

European Association for Cancer Research (EACR) Annual Meeting 2023; 2023 June 12-15; Turin, Italy

Posters acknowledging Oncobiome:

Abstract P-0321: Small non-coding RNA profiling in human tissue and stool samples for the identification of potential biomarkers for CRC early diagnosis
Carla Di Battista, Sonia Tarallo, Amedeo Gagliardi, Giulia Francescato, Francescato4, Giulio Ferrero, Eva Budinska, Veronika Vymetalkova, Pavel Vodicka, Barbara Pardini, Alessio Naccarati
Abstract P-0012: Integrative omic analysis of faecal samples shows novel miRNA-mediated host-microbiota interactions in colorectal cancer
Giulio Ferrero, Barbara Pardini, Sonia Tarallo, Barbora Zwinsová, Ludmila Vodickova, Pavel Vodicka, Nicola Segata, Francesca Cordero, Eva Budinska, Alessio Naccarati
Abstract P-0530: Fecal miRNA profiles and metagenome composition in a mouse model for Lynch syndrome and in humans carrying the disease mutations
Giulia Francescato, Giulio Ferrero, Marc Beltrà Bach, Sonia Tarallo, Carlijn Bruggeling, Fabio Penna, Paola Costelli, Annemarie Boleij, Barbara Pardini, Alessio Naccarati
Abstract P-0570: A multi-omics approach to investigate how the stool miRNome and microbiome reflect CMS subtyping for colorectal cancer classification.
Amedeo Gagliardi, Giulia Francescato, Giulio Ferrero, Sonia Tarallo, Giulia Piaggeschi, Antonio Francavilla, Carla Di Battista1, Enrico Berrino, Caterina Marchiò, Francesca Cordero, Barbara Pardini, Alessio Naccarati

CURRENT UNDERSTANDING OF COLORECTAL AND PANCREATIC CANCERS (CUCAP)

An international conference organized by the Chaperon project, Faculty of Medicine in Pilsen, Charles University, in cooperation with the Institute of Experimental Medicine CAS (Prague, Czech Republic; May 29 and 30, 2023).

Oral Presentation acknowledging Oncobiome:

Consensus molecular subtyping and other omics in colorectal cancer classification: an integrative approach to improve the classification and its reflection in stool miRNome and metagenome
Barbara Pardini

Oral Presentation acknowledging Oncobiome:

A fecal miRNA signature by small RNA sequencing accurately distinguishes colorectal cancers and adenomas: results from a multicentric international study

Alessio Naccarati

The relevant scientific conferences were regularly identified, carefully selected and participants had the opportunity to provide information on the Project to the relevant target audiences, while introducing ONCOBIOME to various closely related initiatives. Here is provided a list of main events where ONCOBIOME has been presented or quoted.

« Imaging tumor-infiltrating CD8+ T-cells in non-small cell lung cancer patients upon neo-adjuvant treatment with durvalumab” J. de Vries EMIM, 14-18 March 2022 Thessaloniki, Greece
“Microbiota-Centered Interventions for the Future of Immuno-Oncology” L. Zitvogel Transatlantic Exchanges in Immuno-Oncology – Dana Farber / Gustave Roussy Days in Oncology, 13 May 2022
“The cancer associated 8q24 region: evidence of alterations of specific miRNAs in biofluids from colorectal cancer and bladder patient” Francescato G, Gagliardi A … Naccarati A… Poster presentation at the European Association for Cancer Research (EACR) Annual meeting 2022, 20-23 June 2022, Seville Spain
« A Transcriptional and post-transcriptional network analyses in colorectal cancer subtypes and their reflection in surrogate biospecimens” Gagliardi A, Francescato G …Naccarati A. Poster presentation at the European Association for Cancer Research (EACR) Annual meeting 2022, 20-23 June 2022, Seville Spain
« Longitudinal analysis reveals gut microbiota shift during standard therapies in metastatic renal cell carcinoma (mRCC) » C. Alves Costa Silva ESMO Annual meeting, 9-13 September 2022, Paris, France
« Microbiome » L. Derosa ESMO Annual meeting, 9-13 September 2022, Paris, France
“Preventive Anti-inflammatory Diet to Reduce Gastrointestinal Inflammation in Familial Adenomatous Polyposis Patients: A Prospective Pilot Study” Belfiore A, Ciniselli CM, Signoroni S, Gariboldi M, Ferrero G, Illescas O, Mancini A, Rivoltini L, Morelli D, Bruno E, Macciotta A, Ricci MT, Brignola C, Daveri E, Cattaneo L, Gargano G, Apolone G, Milione M, Verderio P, Pasanisi P, Vitellaro M. InSiGHT biennial meeting 14-17 Sept 2022 Jersey City / New York City, USA
« Microbiota-centered Interventions to circumvent primary resistance to I-O » L. Zitvogel ITOC, 22-24 September 2022, Munich, Germany
« Microbiota-centered interventions for IO: the next step? » L. Zitvogel InCIT, 26-27 September 2022 Nantes, France
“Dendritic cells in the tumor microenvironment” J. de Vries PIVAC, 26-29 September 2022, Turin, Italy.
« Integrating the microbiota in our understanding of cancer immunosurveillance » L. Ztivogel CICON, 28 September – 1 October 2022, New York, USA
« The gut-cancer dialogue governing tumor immunosurveillance » L. Zitvogel Cell Symposia Hallmarks of cancer, 30 October – 1 November 2022, San Diego, USA

“Exploring the integration of CMS subtyping and other omics in colorectal cancer classification and its reflection in stool miRNome and metagenome for non-invasive precision medicine.” A. Gagliardi AACR, 14-19 April 2023, Orlando, Florida (poster)
“Fecal miRNA profiles and gut metagenome composition in Lynch syndrome: results from a mouse model study and human subjects” Francescato AACR, 14-19 April 2023, Orlando, Florida (poster) This poster received the AACR-Pezcoller Foundation Scholar-in-Training Award
“Small non-coding RNA profiling in human tissue and stool samples for the identification of potential biomarkers for CRC early diagnosis” Di Battista EACR, 12-15 June 2023, Turin, Italy (poster)
“Integrative omic analysis of faecal samples shows novel miRNA-mediated host-microbiota interactions in colorectal cancer” Ferrero EACR, 12-15 June 2023, Turin, Italy (poster)
“Fecal miRNA profiles and metagenome composition in a mouse model for Lynch syndrome and in humans carrying the disease mutations” Francescato EACR, 12-15 June 2023, Turin, Italy (poster)
“A multi-omics approach to investigate how the stool miRNome and microbiome reflect CMS subtyping for colorectal cancer classification” Gagliardi EACR, 12-15 June 2023, Turin, Italy (poster)
“Consensus molecular subtyping and other omics in colorectal cancer classification: an integrative approach to improve the classification and its reflection in stool miRNome and metagenome” Pardini Current Understanding of Colorectal and Pancreatic Cancers (CUCAP), 29-30 May 2023, Prague, Czech Republic (oral presentation)
“A fecal miRNA signature by small RNA sequencing accurately distinguishes colorectal cancers and adenomas: results from a multicentric international study” Naccarati (CUCAP), 29-30 May 2023, Prague, Czech Republic (oral presentation)
“The gut microbiome and its role in shaping the immunotherapy outcome in cancer”, Piccinno XXXVI Workshop of the European Helicobacter & Microbiota Study Group (EHMSG), 7-9 September 2023, Antwerp, Belgium (oral presentation)
“Advancing Immunotherapy: Imaging Immune Cell Migration with Precision” J. de Vries EMIM, 11-15 March 2024, Porto, Portugal (presentation)
“Dendritic Cell Subsets in the Tumor Microenvironment” de Vries EMBO Workshop 20-23 March 2024, Center of Immunology Marseille Luminy (presentation)
“Microbiota in Anti-Lung Cancer Immunotherapy” Zitvogel Keystone Symposia, 17-20 March 2024 Taipei, Taiwan (oral presentation)
“Fecal microRNA and microbiome profiles in colorectal cancer patients: are they predictor of survival and how do behave in longitudinal samples?” Pardini, AACR, 5-10 April 2024, San Diego, California (poster)
“Exploring the role of Small Non-Coding RNAs in Colorectal Cancer” Gagliardi EACR, 10-13 June 2024, Rotterdam, Netherlands (poster)
“Integrative circRNA profiling from RNA-sequencing of colorectal cancer and adenoma tissues shows a downregulation in early stages of the disease” Camandona EACR, 10-13 June 2024, Rotterdam, Netherlands (poster)
“MET and NMDAR interaction in Colorectal Cancer Pathogenesis” Francescato EACR, 10-13 June 2024, Rotterdam, Netherlands (poster)
“Investigating faecal miRNA profiles in colorectal cancers with mucinous morphology” Alberini EACR, 10-13 June 2024, Rotterdam, Netherlands (poster)
“Longitudinal assessment of fecal microRNAs and microbiome profiles in colorectal cancer: prospects for noninvasive diagnosis and prognostic monitoring” Festa EACR, 10-13 June 2024, Rotterdam, Netherlands (poster)
“Microbiome & (risk of) hereditary GE cancer” Boleij InSight, 19-22 June 2024, Barcelona, Spain (invited oral presentation)
“Gut microbiome associations with colorectal cancer in a pooled analysis of 3,512 individuals from 16 cohorts”, Piccinno 35^th Pezcoller symposium: Cancer as a systemic disease: interactions between tumor and host, 24-25 June 2024, Trento, Italy (poster)
“Effect of anti-inflammatory molecules from food on organoids derived from adenomatous polyps of FAP subjects” M. Gariboldi. 35^th Pezcoller Symposium: Cancer as a systemic disease: interactions between tumor and host. Trento, 24-25 June 2024, Trento, Italy (poster)

The 10° International Human Microbiome Consortium (IHMC) Congress – 22-25 June 2024, Rome, Italy

A session dedicated to ONCOBIOME untitled “ONCOBIOME: a network introducing gut microbiota into oncology” has been organized during the 10° International Human Microbiome Consortium (IHMC) Congress on 22-25 June 2024 in Rome, Italy. The oral presentations from the consortium members were the following:

“What is ONCOBIOME and its net achievements?” L. Zitvogel
“Defining gut dysbiosis for immune-oncology” L. Derosa
“Efficacy of fecal microbial transplantation in melanoma and lung cancer patients” A. Elkrief
“Impact of gut microbiota on the efficacy of neoadjuvant therapies in triple negative breast cancers” C. Denkert
“How can microbiota and metabolism impact on DC based-cancer vaccines in melanoma” K. Bol
“Microbiota evolution with colorectal cancer staging” G. Piccinno
“The microbiome in colorectal cancer stages, tumor location, and genetic instability” G. Piccinno, ISME 19, Cape Town (South Africa), 18-23 August 2024 (oral presentation)
“Pooled analysis reveals that the microbiome is consistently associated with CRC and presents alterations according to tumor stages, primary location and genomic Instability”G. Piccinno, Seminar at University of Torino (Italy) for the PhD in Complex Systems for Quantitative Biomedicine, 27 September 2024 (oral presentation)
“Research and Clinical Practice in Cancer Immunotherapy” G. Kroemer 2nd Immuno-Oncology SPO/SPI Joint Meeting, 19 october 2024, Portugal (oral presentation)
“Exploring Frontiers in Cancer Immunotherapy” L. Zitvogel 2nd Immuno-Oncology SPO/SPI Joint Meeting, 19 october 2024, Portugal (oral presentation)
“The microbiome in colorectal cancer: perspectives on age of onset, stage, anatomic location, and mismatch repair deficiency” G. Piccinno, Microbiome Research Workshop organized by Yamada Lab, Institute of Science, Tokyo (Japan) 07 March 2025 (oral presentation)
“The Microbiota and Cancer Prevention, Diagnosis, and Treatment” L. Zitvogel AACR, 25-30 April 2025, Chicago, Illinois (Chairwoman of the session)
“Optimizing microbiome modulation to enhance cancer immunotherapy efficacy” B. Routy AACR, 25-30 April 2025, Chicago, Illinois (oral presentation)
“Gut dysbiosis: a risk factor for cancer patients” L. Zitvogel AACR, 25-30 April 2025, Chicago, Illinois (oral presentation)
“The human microbiome as a diagnostic and treatment-supporting target in oncology” N. Segata AACR, 25-30 April 2025, Chicago, Illinois (oral presentation)
“Profiling microRNAs in fecal immunochemical test leftover buffer to improve colorectal cancer screening.” A. Naccarati AACR, 25-30 April 2025, Chicago, Illinois (poster)
“Microbiome profiling reveals that fecal microbiota transplantation (FMT) modulates response and toxicity when combined with immunotherapy in patients with lung cancer and melanoma (FMT-LUMINate NCT04951583)” S. Duttagupta AACR, 25-30 April 2025, Chicago, Illinois (poster)
“Microbiome alterations of colorectal cancer according to age of onset, stage, anatomic location, and mismatch repair deficiency” G. Piccinno AACR, 25-30 April 2025, Chicago, Illinois (poster)
“Desaminotyrosine contributes to the anticancer effect of fecal microbial transplantation during immune checkpoint blockade in mice and patients” S. Thomas AACR, 25-30 April 2025, Chicago, Illinois (oral presentation)
“Multipronged approach identifying new hallmarks of antibiotics-mediated immunosuppression in a prospective trial of cancer immunotherapy” C. Alves Costa Silva AACR, 25-30 April 2025, Chicago, Illinois (oral presentation)
“Cancer risk score and interceptive measures in cardiovascular disease patients” L. Zitvogel VIB Conference “Immune niches in cancer and inflammation” 7-9 May 2025, Bruges, Belgium (oral presentation)
“Neutralization of the autophagy-repressive tissue hormone DBI/ACBP enhances anticancer immunosurveillance” G. Kroemer VIB Conference “Immune niches in cancer and inflammation” 7-9 May 2025, Bruges, Belgium (oral presentation)
Presentation for an honorific award delivered to L. Zitvogel by the San Salvatore Foundation, 24 May 2025, Lugano, Switzerland (oral presentation)
“Microbiota Signatures in Patients Receiving Immune Checkpoint Inhibitors” L. Zitvogel ASCO, 30 May-3 June 2025, Chicago, Illinois (Plenary session presentation)
“Gut Microbiota Impacts the Immunogenicity of Vaccines” L. Zitvogel Keystone Symposia “Vaccinology and microbiota” 04-06 June 2025, Washington DC (Scientific organizer and plenary session presentation)
“Large-scale integrative analysis of fecal samples sequencing data from healthy and CRC patients supports novel miRNA-mediated host-microbiota interactions” A. Camandona (IIGM) EACR, 16-19 June 2025, Lisbon, Portugal (Poster presentation)
“Characterization of miRNA profiles in different subtypes of colorectal adenomas in tissue and fecal samples” A. Gagliardi (IIGM) EACR, 16-19 June 2025, Lisbon, Portugal (Poster presentation)
“CRC multi-omics groups reveal distinct tumor microenvironments” B. Zwinsova (MU) EACR, 16-19 June 2025, Lisbon, Portugal (Poster presentation)
“Learning about gut dysbiosis and its potential therapies for cancer immunotherapy” L. Zitvogel Science AAAS 30 July 2025, webinar (oral presentation)
Gene Expression-based Subtyping of Early Triple-Negative Breast Cancer (TNBC) for Prediction of Response to Neoadjuvant Immune-chemotherapy in the NSABP B-59/GBG-96-GeparDouze Trial. C. Denkert Abstract submitted for San Antonio Breast Cancer Conference (SABCS) 2025

Paris Immuno-Oncology (PIO) international conference 2025

The final event of ONCOBIOME has been organised concomitantly to the Paris Immuno-Oncology (PIO) international conference. During the PIO 2025, six talks and seven posters summarizing the results of the project have been presented to the scientific community by the consortium members:

“Functional Profiling of the Cancer-Associated Microbiome: A Constraint-Based Approach to Identifying Core Microbial Communities” F. Cordero (oral presentation)
“Modulation of tumor-microenvironment and biomarker strategies in breast cancer immunotherapy” C. Denkert (oral presentation)
“A neuroendocrine factor controlling the cancer-immunity dialogue” G. Kroemer (oral presentation)
“Cancer Proteogenomics- Bridging the Genotype – Phenotype Gap with Molecular Data” J. Lehtiö (oral presentation)
“Strategies to improve the microbiome composition from bench to bedside” B. Routy (oral presentation)
“Gut dysbiosis is a risk factor for immunoresistance in oncology and vaccines” L. Zitvogel (oral presentation)
“Characterization of the gut microbiome for incident cancers in 4,683 individuals” A. Boleij (poster)
“Integrating Tumor Immune Profiling and Gut Microbiome for Prognostic Stratification in Colorectal Cancer Patients” E. Budinska (poster)
“Large-scale integrative analysis of fecal samples sequencing data supports novel miRNA-mediated host-microbiota interactions” G. Ferrero (poster)
“A low-inflammatory diet induces beneficial gut microbiome shifts in individuals with Familial Adenomatous Polyposis” M. Gariboldi (poster)
“Fecal microbiome of High-Progressive melanoma patients impairs CAR T cell activity” L. Heinzerling (poster)
“Gut microbiome composition and fecal miRNA profiles in Lynch syndrome a study on human subjects and a mouse model” B. Pardini (poster)
“Microbiome alterations of colorectal cancer according to age of onset, stage and anatomic location” G. Piccinno (poster)