Présentation et prix ASCO 21

Le parisien ASCO 2021
Quand des bactéries de l’intestin aident à lutter contre le cancer

Oral administration of Akkermansia muciniphila elevates systemic antiaging and anticancer metabolites Claudia Grajeda-Iglesias Sylvère Durand,* Romain Daillère, Kristina Iribarren, Fabien Lemaitre, Lisa Derosa, Fanny Aprahamian, Noélie Bossut, Nitharsshini Nirmalathasan, Frank Madeo, Laurence Zitvogel, Guido Kroemer (2021). Aging (Albany NY). 13, Advance.

Physiologic colonic uptake of 18F-FDG on PET/CT is associated with clinical response and gut microbiome composition in patients with advanced non-small cell lung cancer treated with immune checkpoint inhibitors.
Cvetkovic L, Régis C, Richard C, Derosa L, Leblond A, Malo J, Messaoudene M, Desilets A, Belkaid W, Elkrief A, Routy B, Juneau D.Eur J Nucl Med Mol Imaging.
2020 Oct 31. doi: 10.1007/s00259-020-05081-6. Online ahead of print.PMID: 33128571

The Gut Microbiome Associates with Immune Checkpoint Inhibition Outcomes in Patients with Advanced Non-Small Cell Lung Cancer.
Hakozaki T, Richard C, Elkrief A, Hosomi Y, Benlaïfaoui M, Mimpen I, Terrisse S, Derosa L, Zitvogel L, Routy B, Okuma Y.Cancer Immunol Res.
2020 Oct;8(10):1243-1250. doi: 10.1158/2326-6066.CIR-20-0196. Epub 2020 Jul 27.PMID: 32847937

Altered Fecal Small RNA Profiles in Colorectal Cancer Reflect Gut Microbiome Composition in Stool Samples
Sonia Tarallo, Giulio Ferrero, Gaetano Gallo, Antonio Francavilla, Giuseppe Clerico, Alberto Realis Luc, Paolo Manghi, Andrew Maltez Thomas, Paolo Vineis, Nicola Segata, Barbara Pardini, Alessio Naccarati, Francesca Corderoa

A Holistic Perspective: Exosomes Shuttle between Nerves and Immune Cells in the Tumor Microenvironment
Mihnea P. Dragomir, Vlad Moisoiu, Roxana Manaila, Barbara Pardini, Erik Knutsen, Simone Anfossi, Moran Amit and George A. Calin

Trial watch : the gut microbiota as a tool to boost the clinical efficacy of anticancer immunotherapy
Romain Daillère, Lisa Derosa , Mélodie Bonvalet, Nicola Segata, Bertrand Routy, Manuela Gariboldi, Eva Budinská, I. Jolanda M. De Vries, Alessio Gordon Naccarati, Valérie Zitvogel, Carlos Caldas, Lars Engstrand, Sibylle Loilbl, Jacques Fieschi, Lucie Heinzerling, Guido Kroemer & Laurence Zitvogel

Intake of Natural Compounds and Circulating microRNA Expression Levels: Their Relationship Investigated in Healthy Subjects With Different Dietary Habits
Giulio Ferrero, Sara Carpi, Beatrice Polini, Barbara Pardini, Paola Nieri, Alessia Impeduglia, Sara Grioni, Sonia Tarallo and Alessio Naccarati

Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals.
Asnicar, F., Berry, S.E., Valdes, A.M. et al.
Nat Med 27, 321–332 (2021).

Analysis of 1321 Eubacterium rectale genomes from metagenomes uncovers complex phylogeographic population structure and subspecies functional adaptations.
Karcher, N., Pasolli, E., Asnicar, F. et al.
Genome Biol 21, 138 (2020).

The Prevotella copri Complex Comprises Four Distinct Clades Underrepresented in Westernized Populations,
Adrian Tett, Kun D. Huang, Francesco Asnicar, Hannah Fehlner-Peach, Edoardo Pasolli, Nicolai Karcher, Federica Armanini, Paolo Manghi, Kevin Bonham, Moreno Zolfo, Francesca De Filippis, Cara Magnabosco, Richard Bonneau, John Lusingu, John Amuasi, Karl Reinhard, Thomas Rattei, Fredrik Boulund, Lars Engstrand, Albert Zink, Maria Carmen Collado, Dan R. Littman, Daniel Eibach, Danilo Ercolini, Omar Rota-Stabelli, Curtis Huttenhower, Frank Maixner, Nicola Segata.
Cell Host & Microbe, Volume 26, Issue 5, 2019